Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

Objectives: The purpose of this study was to comprehensively examine cardiovascular
reserve function with exercise in patients with heart failure and preserved ejection fraction …

Objectives: This study sought to define the prevalence, severity, and significance of
pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) in the …

Ventricular remodelling describes structural changes in the left ventricle in response to
chronic alterations in loading conditions, with three major patterns: concentric remodelling …

Background—Nearly half of patients with heart failure have a preserved ejection fraction
(HFpEF). Symptoms of exercise intolerance and dyspnea are most often attributed to …

Background—In heart failure (HF), a defective nitric oxide signaling is involved in left
ventricular (LV) diastolic abnormalities and remodeling. PDE5 inhibition, by blocking …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

Nearly half of all patients who have heart failure have preserved ejection fraction (HFpEF).
Patients who have HFpEF tend to be older, female, and hypertensive, and characteristically …

Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …