Herein we summarize important discoveries made over many years about Leydig cell
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …

Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the
rat as a model system, it was found that age-related reductions in serum TS were not due to …

Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor,
is a mitochondrial outer membrane protein implicated as essential for cholesterol import to …

Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a
transmembrane protein located on the outer mitochondria membrane (OMM) and mainly …

Translocator protein (18 kDa)(TSPO) is a ubiquitous mitochondrial protein. Studies of its
responses to drug and endogenous ligands have shown TSPO to be involved either directly …

Leydig cell testosterone (T) production is reduced with age, resulting in reduced serum T
levels (hypogonadism). A number of cellular changes have been identified in the …

Steroidogenesis begins with cholesterol transfer into mitochondria through the
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …

TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral
tissue binding sites for benzodiazepines, and was formerly called the peripheral …

Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor
(PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate …

The mitochondrial translocator protein (18 kDa; TSPO) is a high‐affinity cholesterol‐binding
protein that is an integral component of the cholesterol trafficking scaffold responsible for …