Plants as a source of anticancer agents: From bench to bedside
Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …
Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …
the public health system. The high toxicity and the lack of selectivity of conventional …
Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach
Methotrexate (MTX) is a drug which is used to treat different types of cancers but
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …
Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
AM Mahmoud, OE Hussein, WG Hozayen… - … Science and Pollution …, 2020 - Springer
Liver injury is one of the adverse effects of methotrexate (MTX). Ferulic acid (FA) is an
antioxidant phytochemical that confers hepatoprotective efficacy; however, its effect against …
antioxidant phytochemical that confers hepatoprotective efficacy; however, its effect against …
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
AM Mahmoud, WG Hozayen, SM Ramadan - Biomedicine & …, 2017 - Elsevier
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …
one of the most effective natural supplements available; however, its ameliorative …
Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid
AM Mahmoud, OE Hussein, WG Hozayen… - Chemico-biological …, 2017 - Elsevier
Abstract 18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice with promising
hepatoprotective activity. However, its protective mechanism on methotrexate (MTX) …
hepatoprotective activity. However, its protective mechanism on methotrexate (MTX) …
Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity
HM Abo-Haded, MA Elkablawy, Z Al-Johani… - PloS one, 2017 - journals.plos.org
Sitagliptin is selective dipeptidyl peptidase-4 inhibitor (DPP4-I), used clinically as a new oral
anti-diabetic agent. This study explored the underlying mechanisms of the hepatoprotective …
anti-diabetic agent. This study explored the underlying mechanisms of the hepatoprotective …
[HTML][HTML] The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced …
Berberine (BBR) is a natural compound of plant origin belonging to isoquinoline type of
alkaloid. Methotrexate (MTX) is an anti-metabolite used widely for a variety of tumors and …
alkaloid. Methotrexate (MTX) is an anti-metabolite used widely for a variety of tumors and …
[HTML][HTML] Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities
Abstract Nigella sativa (N. sativa), which belongs to the botanical family of Ranunculaceae,
is a widely used medicinal plant all over the world. N. sativa seeds and oil have been used …
is a widely used medicinal plant all over the world. N. sativa seeds and oil have been used …
Alleviation of liver dysfunction, oxidative stress and inflammation underlies the protective effect of ferulic acid in methotrexate-induced hepatotoxicity
M Roghani, H Kalantari, MJ Khodayar… - Drug design …, 2020 - Taylor & Francis
Introduction In multiple studies, involvement of oxidative stress in the pathogenesis of
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …