Shiga toxin (Stx) is one of the most potent bacterial toxins known. Stx is found in Shigella
dysenteriae 1 and in some serogroups of Escherichia coli (called Stx1 in E. coli). In addition …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …

Summary Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-
dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport …

Proteins routed to the secretory pathway start their journey by being transported across
biological membranes, such as the endoplasmic reticulum. The essential nature of this …

Eeyarestatin 24 (ES24) is a promising new antibiotic with broad-spectrum activity. It shares
structural similarity with nitrofurantoin (NFT), yet appears to have a distinct and novel …

The endoplasmic reticulum (ER) plays critical roles in the processing of secreted and
transmembrane proteins. To deliver small molecules to this organelle, we synthesized …

Covering: up to the end of 2019 Diverse natural product small molecules have allowed
critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically …

Vaccination is a widely‐accepted resort against the invasion or proliferation of bacteria,
parasites, viruses, and even cancer, which accounts heavily on an active involvement of …

Whilst the co-translational translocation of nascent proteins across the mammalian
endoplasmic reticulum (ER) is well defined, the capacity of this organelle for post …