Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …

Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Two complementary approaches were used in search of the intracellular targets of the toxic
PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of …

The mechanical behaviour of cells is largely controlled by a structure that is fundamentally
out of thermodynamic equilibrium: a network of crosslinked filaments subjected to the action …

Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

The nuclear lamina is a fundamental constituent of metazoan nuclei. It is composed mainly
of lamins, which are intermediate filament proteins that assemble into a filamentous …

The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …