Since 1928, human fetal tissues and stem cells have been used worldwide to treat various
conditions. Although the transplantation of the fetal midbrain substantia nigra and …

Primordial germ cells (PGCs) are the embryonic precursors of the gametes and represent
the founder cells of the germline. Specification of PGCs is a critical divergent point during …

Human primordial germ cells and mouse neonatal and adult germline stem cells are
pluripotent and show similar properties to embryonic stem cells. Here we report the …

Background Germ cells arise from a small group of cells that express markers of
pluripotency including OCT4. In humans formation of gonadal compartments (cords in testis …

The first histological observations about the origin of the precursors of gametes termed
primordial germ cells (PGCs) in extragonadal regions and their subsequent migration into …

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

US7541185B2 - Methods for identifying factors for differentiating definitive endoderm -
Google Patents US7541185B2 - Methods for identifying factors for differentiating definitive …

Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition
(2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen synthase …

Pluripotency is defined as the potential of a cell to differentiate into cells of the three germ
layers: endoderm, mesoderm and ectoderm. In vivo, the presence of pluripotent stem cells is …

Abstract NANOG, POU5F1, and SOX2 are required by the inner cell mass of the blastocyst
and act cooperatively to maintain pluripotency in both mouse and human embryonic stem …