Group 1 metabotropic glutamate receptor expression defines a T cell memory population during chronic Toxoplasma infection that enhances IFN-gamma and perforin …

EA Vizcarra, A Ulu, TA Landrith, X Qiu, A Godzik… - Brain, Behavior, and …, 2023 - Elsevier
Within the brain, a pro-inflammatory response is essential to prevent clinical disease due to
Toxoplasma gondii reactivation. Infection in the immunocompromised leads to lethal …

The small molecule ephrin receptor inhibitor, GLPG1790, reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma …

GL Gravina, A Mancini, A Colapietro, S Delle Monache… - Cancers, 2019 - mdpi.com
Therapies against glioblastoma (GBM) show a high percentage of failure associated with the
survival of glioma stem cells (GSCs) that repopulate treated tumours. Forced differentiation …

Vitamin B12 in cats: nutrition, metabolism, and disease

G Siani, B Mercaldo, MC Alterisio, A Di Loria - Animals, 2023 - mdpi.com
Simple Summary We review the role of vitamin B12 in cats. Cobalamin is an essential part of
enzymes involved in multiple metabolic reactions. In mammals, two enzymes are cobalamin …

Impacts of some clinicopathodemography and colorectal tissues key cell cycle and mucin stabilizing molecules on the metastasis trend in colorectal cancer patients

A Ghorbani Ranjbary, J Mehrzad, N Rahbar… - Molecular Biology …, 2023 - Springer
Background We aimed to evaluate the various clinicopathodemographical, epidemiological,
and molecular contributors to cumulatively worldwide metastatic colorectal cancer (CRC) in …

Proposal for a new diagnostic histopathological approach in the evaluation of Ki-67 in GEP-NETs

P Faviana, L Boldrini, C Gentile, PA Erba, E Sammarco… - Diagnostics, 2022 - mdpi.com
Introduction: Studies have shown that the Ki-67 index is a valuable biomarker for the
diagnosis, and classification of gastro-entero-pancreatic neuroendocrine tumors (GEP …

Radiation-Activated Cobalamin-Kinase Inhibitors for Treatment of Pancreatic Ductal Adenocarcinoma

LN Gendron, CG Sheveland, JR Gunn… - Molecular …, 2023 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most dismal diagnoses that a
patient can receive. PDAC is extremely difficult to treat, as drug delivery is challenging in …

The Avian Retroviral Receptor Tva Mediates the Uptake of Transcobalamin Bound Vitamin B12 (Cobalamin)

V Krchlíková, J Mikešová, J Geryk, C Bařinka… - Journal of …, 2021 - Am Soc Microbiol
The avian sarcoma and leukosis viruses (ASLVs) are important chicken pathogens. Some of
the virus subgroups, including ASLV-A and K, utilize the Tva receptor for cell entrance …

3D chick embryo chorioallantoic membrane model as an in vivo model to study morphological and histopathological features of feline fibrosarcomas

K Zabielska-Koczywąs, A Wojtkowska, I Dolka… - BMC Veterinary …, 2017 - Springer
Background The chick embryo chorioallantoic membrane (CAM) model is well described in
human medicine as a cost-effective, easy to perform preclinical oncological model for …

[HTML][HTML] Serum Transcobalamin Concentration in Cats—Method Validation and Evaluation in Chronic Enteropathies and Other Conditions

T Kunath, S Kather, F Dengler, E Nexo… - Veterinary …, 2024 - mdpi.com
Hypocobalaminemia is common in cats with chronic enteropathy (FCE). However, the
disruptions in cobalamin metabolism are not fully understood and may vary across species …

Role of Ki67 protein in colorectal cancer

I Mulyawan - 2019 - pesquisa.bvsalud.org
Colorectal cancer has become one of the most frequent malignancy and the leading cause
of death from cancer globally. Global Burden Cancer in 2013 had placed colorectal cancer …