Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Recent advancements in snake antivenom production

AS Rathore, R Kumar, OS Tiwari - International journal of biological …, 2023 - Elsevier
Snakebite envenoming (SBE), a neglected tropical disease, claims lives of about 138,000
people globally, and antivenom is the only approved treatment worldwide. However, this …

[HTML][HTML] An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory …

RN Patel, RH Clare, L Ledsgaard, M Nys, J Kool… - Biochemical …, 2023 - Elsevier
Snakebite envenoming is a neglected tropical disease that causes over 100,000 deaths
annually. Envenomings result in variable pathologies, but systemic neurotoxicity is among …

From squid giant axon to automated patch-clamp: electrophysiology in venom and antivenom research

S Ahmadi, M Benard-Valle, K Boddum… - Frontiers in …, 2023 - frontiersin.org
Ion channels play a crucial role in diverse physiological processes, including
neurotransmission and muscle contraction. Venomous creatures exploit the vital function of …

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

M Benard-Valle, Y Wouters, A Ljungars… - Nature …, 2024 - nature.com
Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions
of similar and dissimilar antigens, making them versatile tools for the treatment of eg …

De novo designed proteins neutralize lethal snake venom toxins

S Vázquez Torres, M Benard Valle, SP Mackessy… - Nature, 2025 - nature.com
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over
100,000 lives annually and causing severe complications and long-lasting disabilities for …

De novo designed proteins neutralize lethal snake venom toxins

SV Torres, MB Valle, SP Mackessy… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over
100,000 lives annually and causing severe complications and long-lasting disabilities for …

[HTML][HTML] Current Technologies in Snake Venom Analysis and Applications

H Roman-Ramos, PL Ho - Toxins, 2024 - mdpi.com
This comprehensive review explores the cutting-edge advancements in snake venom
research, focusing on the integration of proteomics, genomics, transcriptomics, and …

[HTML][HTML] Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants

CM Moore, A Ljungars, MJ Paul, CH Dahl, S Ahmadi… - Toxicon, 2023 - Elsevier
Current snakebite antivenoms are based on polyclonal animal-derived antibodies, which
can neutralize snake venom toxins in envenomed victims, but which are also associated …

De novo design of protein binders to bioactive peptides: from hormones to snake toxins

SV Torres - 2024 - search.proquest.com
Recent advancements in deep learning methods for protein design and structure prediction
have demonstrated the potential of de novo proteins to replace antibodies as affinity …