The homeobox domain transcription factor NANOG, a key regulator of embryonic
development and cellular reprogramming, has been reported to be broadly expressed in …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …

An increasing number of women fail to achieve pregnancy due to either failed fertilization or
embryo arrest during preimplantation development. This often results from decreased oocyte …

Self-renewal and pluripotency are two major characteristics of embryonic stem cells (ESCs)
that allow ESCs to maintain stem cell population, and differentiate into multiple types of adult …

The mitochondrial genome resides in the mitochondria present in nearly all cell types. The
porcine (Sus scrofa) mitochondrial genome is circa 16.7 kb in size and exists in the …

N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of
somatic cells into induced pluripotent stem cells. However, the role of m6A methylation in …

Abstract KDM5B (JARID1B/PLU1) is a H3K4me2/3 histone demethylase that is implicated in
cancer development and proliferation and is also indispensable for embryonic stem cell self …

It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …

Genetic modification of animals via selective breeding is the basis for modern agriculture.
The current breeding paradigm however has limitations, chief among them is the …