[HTML][HTML] Genetics of wellbeing and its components satisfaction with life, happiness, and quality of life: A review and meta-analysis of heritability studies
M Bartels - Behavior genetics, 2015 - Springer
Wellbeing is a major topic of research across several disciplines, reflecting the increasing
recognition of its strong value across major domains in life. Previous twin-family studies …
recognition of its strong value across major domains in life. Previous twin-family studies …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
RK Walters, R Polimanti, EC Johnson… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …
polygenic architecture or its genetic relationship with other disorders. To discover loci …
[HTML][HTML] Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Metabolomics examines the small molecules involved in cellular metabolism. Approximately
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …
because of limitations on sample size in previous studies. Subjective well-being, a …
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome …
than cognitive ability. We used genomic structural equation modeling and prior genome …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Multivariate genome-wide analyses of the well-being spectrum
We introduce two novel methods for multivariate genome-wide-association meta-analysis
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
The Netherlands twin register: longitudinal research based on twin and twin-family designs
L Ligthart, CEM van Beijsterveldt… - Twin Research and …, 2019 - cambridge.org
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …
their parents, siblings, spouses and other family members participate. Here we describe the …
[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …
birth complications. Many maternal obesity-related traits are observationally associated with …
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
novel insights into disease pathogenesis. We did an epigenome-wide association study to …