The integration of realist evaluation principles within randomised controlled trials ('realist
RCTs') enables evaluations of complex interventions to answer questions about what works …

Background Even under optimal internal organizational conditions, implementation can be
undermined by changes in organizations' external environments, such as fluctuations in …

Many interventions are not disruptive enough of the patterns that entrench poor health and
health inequities. Ways forward may require a break with tradition to embrace system …

Abstract Introduction In 2014, the South African government adopted a differentiated service
delivery (DSD) model in its “National Adherence Guidelines for Chronic Diseases (HIV, TB …

Objectives The overuse of antimalarial drugs is widespread. Effective methods to improve
prescribing practice remain unclear. We evaluated the impact of 10 interventions that …

Background: Community participation in global health interventions may improve outcomes
and solve complex health issues. Although numerous community participatory approaches …

Health systems in many African countries are failing to provide populations with access to
good quality health care. Morbidity and mortality from curable diseases such as malaria …

Microbial larviciding can be an effective component of integrated vector management
malaria control schemes, although it is not commonly implemented. Moreover, quality …

The ways in which dimensions of health and healthcare intersect with economics and
politics in particular contexts requires close attention. In this article we connect concerns …

Background Clinical trials conducted in Africa often require substantial investments to
support trial centres and public health facilities. Trial resources could potentially generate …