Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

Circulating cytokines and growth factors are regulators of inflammation and have been
implicated in autoimmune and metabolic diseases. In this genome-wide association study …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

The majority of genetic variants associated with common human diseases map to
enhancers, non-coding elements that shape cell-type-specific transcriptional programs and …

The developmental programs that generate a broad repertoire of regulatory T cells (Treg
cells) able to respond to both self antigens and non-self antigens remain unclear. Here we …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …

Motivation Population-scale sequenced cohorts are foundational resources for genetic
analyses, but processing raw reads into analysis-ready cohort-level variants remains …

Context Estradiol is the primary female sex hormone and plays an important role for skeletal
health in both sexes. Several enzymes are involved in estradiol metabolism, but few …