Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …

Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

Changes in the composition of gut-associated microbial communities are associated with
many human illnesses, but the factors driving dysbiosis remain incompletely understood …

Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to
glycine or taurine to increase their solubility, secreted into bile, concentrated in the …

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition affecting one quarter of the
global population. Although primarily linked to obesity and metabolic syndrome …

Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disorder of
the gastrointestinal tract that arises due to complex interactions between host genetic risk …

Bile acids are cholesterol-derived surfactants that circulate actively between the liver and
ileum and that are classically recognized for emulsifying dietary lipids to facilitate absorption …

Following birth, the neonatal intestine is exposed to maternal and environmental bacteria
that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect …

Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …