Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

Principles of intracellular protein synthesis and protein degradation remain to be among the
most challenging questions of modern cell biology. Proteolysis plays an important role in …

Three different proteolytic processes have been shown to be important in the generation of
antigenic peptides displayed on MHC-class I molecules. The great majority of these …

Over the past decade there has been considerable progress in understanding how MHC
class I-presented peptides are generated. The emerging theme is that the immune system …

Thermoplasma acidophilum is a thermoacidophilic archaeon that thrives at 59° C and pH 2,
which was isolated from self-heating coal refuse piles and solfatara fields,. Species of the …

An alanyl-alanyl-phenylalanyl-7-amino-4-methylcoumarin–hydrolyzing protease particle
copurifying with 26 S proteasomes was isolated and identified as tripeptidyl peptidase II …

Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain
a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism …

The degradation of cellular proteins by proteasomes generates peptides 2–24 residues
long, which are hydrolyzed rapidly to amino acids. To define the final steps in this pathway …

One of the most precisely regulated processes in living cells is intracellular protein
degradation. The main component of the degradation machinery is the 20S proteasome …