The healthy periodontium provides the support necessary to maintain teeth in adequate
function. It is comprised of four principal components: namely, the gingiva, periodontal …

Integrins are remarkably multifunctional: they mediate cell adhesion and migration,
orchestrate organization of the actin-based cytoskeleton, and activate signal transduction …

THE intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally
identified by its high level of tyrosine phosphorylation in v-src-transformed cells1á¤-4. FAK is …

Shear stress, the tangential component of hemodynamic forces, activates the extracellular
signal-regulated kinase (ERK) and c-Jun NH 2-terminal kinase (JNK) signal transduction …

Chondrocyte differentiation is a multi‐step process characterized by successive changes in
cell morphology and gene expression. In addition to tight regulation by numerous soluble …

Interaction of type I collagen (COL (I)) with α2β1 integrin causes differentiation and
transforming growth factor (TGF)-β receptor down-regulation in osteoblastic cells (Takeuchi …

The extracellularly-responsive kinase (ERK) subfamily of mitogen-activated protein kinases
(MAPKs) has been implicated in the regulation of cell growth and differentiation. Activation of …

Adenoviruses (Ad) are a significant cause of acute infections in humans; however,
replication-defective forms of this virus are currently under investigation for human gene …

Integrins mediate cell adhesion and motility on the extracellular matrix, yet they also promote
viral attachment and/or entry. Evidence is presented that adenovirus internalization by …

Integrin-linked kinase (ILK) is a multidomain focal adhesion (FA) protein that functions as an
important regulator of integrin-mediated processes. We report here the identification and …