Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase
activities. Among prostaglandins (PGs), prostacyclin (PGI 2) and PGE 2 are strongly involved …

Mild-to-moderate pulmonary hypertension (PH) is a common complication of chronic
obstructive pulmonary disease (COPD). It is characterized by narrowing and thickening of …

Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an
alternative to antivirals to treat human infectious diseases, especially influenza virus …

Pulmonary arterial (PA) stiffness is associated with increased mortality in patients with
pulmonary hypertension (PH); however, the role of PA stiffening in the pathogenesis of PH …

Pulmonary arterial hypertension (PAH) is a life-threatening disease with limited survival.
Herein, we propose the pharmacological inhibition of Gq proteins as a novel concept to …

Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with
subcutaneous, intravenous (iv), oral, and inhaled routes of administration for the treatment of …

Pulmonary arterial hypertension (PAH) is a progressive vascular remodelling disease where
patients ultimately die from heart failure. Increased production of vasoconstrictors …

Selexipag is a compound that was designed to overcome the issues associated with oral
administration of prostanoid compounds, beraprost and treprostinil in the treatment of …

Treprostinil (TRE) is a potent pulmonary vasodilator with effects on other pathological
aspects of pulmonary arterial hypertension. In this study, the prostanoid receptors involved …

Background and purpose Beraprost is a prostacyclin analogue and IP receptor agonist
which is approved to treat pulmonary arterial hypertension (PAH) in Asia. The beraprost-314 …