The beneficial effects of statins are the result of their capacity to reduce cholesterol
biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the …

Significant advances in the management of cardiovascular disease have been made
possible by the development of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) …

Clinical trials of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or
statin therapy have demonstrated that baseline or treated low-density lipoprotein (LDL) …

Hypertension, which is characterized by multiple alterations in the structure and function of
the cell membrane, is often associated with important metabolic abnormalities including …

Atherosclerotic plaque rupture and erosions precipitate thrombus formation and may lead to
an acute ischemic syndrome. Lipids and lipoproteins modulate the expression and/or …

The pathophysiology of the association between cholesterol and atherosclerosis has been
thought to involve the deposition, modification, and cellular uptake of cholesterol. We now …

Low density lipoprotein (LDL) and fibrinogen apheresis was recently reported to be an
effective therapy in sudden hearing loss (SHL). In this study, we investigated whether …

Background Recent clinical trials and meta-analyses of β-hydroxy-β-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors (statins) have demonstrated a reduction in …

Objectives While lipid metabolism disorder is widely acknowledged as a contributing factor
to inflammation, the association between remnant cholesterol (RC), which indicates lipid …

Stroke is a major cause of mortality and morbidity. The epidemiologic association between
elevated serum cholesterol and stroke risk is controversial. However, recent secondary …