Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis

Z Mei, Y Liu, C Liu, A Cui, Z Liang, G Wang… - British journal of …, 2014 - nature.com
Background: The role of tumour-infiltrating inflammation in the prognosis of patients with
colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta …

Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us

L Hlatky, P Hahnfeldt, J Folkman - Journal of the National …, 2002 - academic.oup.com
A substantial number of clinical trials using antiangiogenic therapies are ongoing worldwide.
How to achieve the maximum benefit from these therapies and how to monitor patient …

Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

G Des Guetz, B Uzzan, P Nicolas, M Cucherat… - British journal of …, 2006 - nature.com
We performed a meta-analysis of all published studies relating intratumoural microvessel
density (MVD)(45 studies) or vascular endothelial growth factor (VEGF) expression (27 …

The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer

CSD Roxburgh, DC McMillan - Cancer treatment reviews, 2012 - Elsevier
Colorectal cancer progression and survival is dependent on complex interactions between
the tumour and the host. The pronounced local inflammatory response in and around the …

The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis

Y Zhao, X Ge, J He, Y Cheng, Z Wang, J Wang… - World journal of surgical …, 2019 - Springer
Purpose In colorectal cancer (CRC), whether the immune score can be used to predict the
clinical prognosis of the patient has not been completely established. Besides, the …

Therapeutic targeting of the colorectal tumor stroma

WH Fridman, I Miller, C Sautès-Fridman, AT Byrne - Gastroenterology, 2020 - Elsevier
Colorectal tumors have been classified based on histologic factors, genetic factors, and
consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of …

[HTML][HTML] The local inflammatory response in colorectal cancer–type, location or density? A systematic review and meta-analysis

PG Alexander, DC McMillan, JH Park - Cancer treatment reviews, 2020 - Elsevier
Introduction The host anti-tumour inflammatory response is a strong prognostic indicator,
and tumour infiltrating lymphocytes (TILs) are believed to have a complimentary role …

Functional imaging of colorectal cancer angiogenesis

V Goh, AR Padhani, S Rasheed - The Lancet Oncology, 2007 - thelancet.com
Angiogenesis is a key factor in the growth and dissemination of colorectal cancer, with
significant implications for its clinical management. Previous trials have provided proof-of …

Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches

RTP Poon, ST Fan, J Wong - Annals of surgery, 2003 - journals.lww.com
Objective To review the current data on the prognostic and therapeutic implications of tumor
angiogenesis in gastrointestinal cancers. Summary Background Data Numerous studies …

The angiogenic switch occurs at the adenoma stage of the adenoma–carcinoma sequence in colorectal cancer

CA Staton, ASA Chetwood, IC Cameron, SS Cross… - Gut, 2007 - gut.bmj.com
Objective: The aim of this study was to examine the relationship between tissue factor (TF),
vascular endothelial growth factor (VEGF) and the onset of angiogenesis in the adenoma …