Tendon aging is associated with an increasing prevalence of tendon injuries and/or chronic
tendon diseases, such as tendinopathy, which affects approximately 25% of the adult …

Bio-factor stimulation is essential for axonal regeneration in the central nervous system.
Thus, persistent and efficient factor delivery in the local microenvironment is an ideal …

Spinal cord injury often results in devastating consequences for those afflicted, with very few
therapeutic options. A central element of spinal cord injuries is astrogliosis, which forms a …

Background The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored
previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro …

Spinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient's life, with
far-reaching social and economic effects. A consequential sequence of SCI is the significant …

The goal of this work was to design a polymer‐based platform capable of localized, long‐
term delivery of biologically active neurotropic factors using an affinity‐based approach …

Nonviral mRNA delivery is an attractive therapeutic gene delivery strategy, as it achieves
efficient protein overexpression in vivo and has a desirable safety profile. However, mRNA's …

Spinal cord injury (SCI) is a devastating trauma that currently affects 54 people out of every
million, which is approximately 270,000 people in the United States (National Spinal Cord …

A spinal cord injury can damage neuronal connections required for both motor and sensory
function. Barriers to regeneration within the central nervous system, including an absence of …

Objective This study sought to promote the adhesion, proliferation and differentiation of rat
bone marrow mesenchymal stem cells by constructing a neurotrophin-3 (NT-3) sustained …