Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates

J Nair, VHS Kumar - Children, 2018 - mdpi.com
Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Association of high-dose erythropoietin with circulating biomarkers and neurodevelopmental outcomes among neonates with hypoxic ischemic encephalopathy: A …

SE Juul, E Voldal, BA Comstock, AN Massaro… - JAMA network …, 2023 - jamanetwork.com
Importance The ability to predict neurodevelopmental impairment (NDI) for infants
diagnosed with hypoxic ischemic encephalopathy (HIE) is important for parental guidance …

Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway

Y Zheng, L Li, B Chen, Y Fang, W Lin, T Zhang… - Cell Communication and …, 2022 - Springer
Background Neonatal hypoxic-ischemic brain injury (HIE) is caused by perinatal asphyxia,
which is associated with various confounding factors. Although studies on the pathogenesis …

Neuroprotective therapies in the NICU in term infants: present and future

EJ Molloy, M El-Dib, SE Juul, M Benders… - Pediatric …, 2023 - nature.com
Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

Early predictors of perinatal brain damage: the role of neurobiomarkers

I Bersani, F Pluchinotta, A Dotta, I Savarese… - Clinical Chemistry and …, 2020 - degruyter.com
The early detection of perinatal brain damage in preterm and term newborns (ie
intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still …

Biomarkers in neonatal hypoxic–ischemic encephalopathy—Review of the literature to date and future directions for research

DM Murray - Handbook of clinical neurology, 2019 - Elsevier
The widespread introduction of therapeutic hypothermia as a standard of care in hypoxic–
ischemic encephalopathy (HIE) has brought increasing pressure on clinicians to make an …

[HTML][HTML] Neuroprotective effects of oxymatrine on hypoxic–ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway

XB Lan, YS Ni, N Liu, W Wei, Y Liu, JM Yang… - Biomedicine & …, 2023 - Elsevier
Neuronal apoptosis is a major pathological process associated with neurological
dysfunction in neonates after hypoxic–ischemic brain damage (HIBD). Our previous study …

Cerebrospinal fluid levels of neuron-specific enolase predict the severity of brain damage in newborns with neonatal hypoxic-ischemic encephalopathy treated with …

MZ León-Lozano, J Arnaez, A Valls, G Arca, T Agut… - PLoS …, 2020 - journals.plos.org
Objectives To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-
NSE) during the first 72 hours correlate with other tools used to assess ongoing brain …

The fetus at the tipping point: modifying the outcome of fetal asphyxia

SK Dhillon, CA Lear, R Galinsky… - The Journal of …, 2018 - Wiley Online Library
Brain injury around birth is associated with nearly half of all cases of cerebral palsy.
Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia …