MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

Computational prediction of drug–target interactions (DTIs) has become an essential task in
the drug discovery process. It narrows down the search space for interactions by suggesting …

Soil organisms have an important role in aboveground community dynamics and ecosystem
functioning in terrestrial ecosystems. However, most studies have considered soil biota as a …

The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …

Cytoscape. js is an open-source JavaScript-based graph library. Its most common use case
is as a visualization software component, so it can be used to render interactive graphs in a …

Autophagy, the process by which proteins and organelles are sequestered in double-
membrane structures called autophagosomes and delivered to lysosomes for degradation …

The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche
remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival …

The cBioPortal for Cancer Genomics (http://cbioportal. org) provides a Web resource for
exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal …

A big challenge in current systems biology research arises when different types of data must
be accessed from separate sources and visualized using separate tools. The high cognitive …

IntAct (freely available at http://www. ebi. ac. uk/intact) is an open-source, open data
molecular interaction database populated by data either curated from the literature or from …