Moxidectin: an oral treatment for human onchocerciasis

P Milton, JID Hamley, M Walker… - Expert Review of Anti …, 2020 - Taylor & Francis
Introduction Moxidectin is a milbemycin endectocide recently approved for the treatment of
human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a …

Onchocerciasis (river blindness)–more than a century of research and control

NW Brattig, RA Cheke, R Garms - Acta Tropica, 2021 - Elsevier
This review summarises more than a century of research on onchocerciasis, also known as
river blindness, and its control. River blindness is an infection caused by the tissue filaria …

[HTML][HTML] Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised …

NO Opoku, DK Bakajika, EM Kanza, H Howard… - The Lancet, 2018 - thelancet.com
Background The morbidity and socioeconomic effects of onchocerciasis, a parasitic disease
that is primarily endemic in sub-Saharan Africa, have motivated large morbidity and …

[HTML][HTML] A roadmap for the development of ivermectin as a complementary malaria vector control tool

TI Roadmappers - The American journal of tropical medicine and …, 2020 - ncbi.nlm.nih.gov
In the context of stalling progress against malaria, resistance of mosquitoes to insecticides,
and residual transmission, mass drug administration (MDA) of ivermectin, an endectocide …

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

SR Doyle, C Bourguinat… - PLoS neglected …, 2017 - journals.plos.org
Background Treatment of onchocerciasis using mass ivermectin administration has reduced
morbidity and transmission throughout Africa and Central/South America. Mass drug …

Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon: impact of more than 13 years of ivermectin

JN Siewe Fodjo, G Tatah, EN Tabah, L Ngarka… - Infectious Diseases of …, 2018 - Springer
Background A high epilepsy prevalence has been reported in several onchocerciasis-
endemic villages along the Mbam and Sanaga river valleys in Cameroon, including Bilomo …

Macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness

M Walker, SDS Pion, H Fang, J Gardon… - Clinical Infectious …, 2017 - academic.oup.com
Background Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to
eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially …

Molecular docking simulation studies identifies potential natural product derived-antiwolbachial compounds as filaricides against onchocerciasis

SK Kwofie, E Broni, FU Yunus, J Nsoh, D Adoboe… - Biomedicines, 2021 - mdpi.com
Onchocerciasis is the leading cause of blindness and severe skin lesions which remain a
major public health problem, especially in tropical areas. The widespread use of antibiotics …

[HTML][HTML] Genome-based tools for onchocerciasis elimination: Utility of the mitochondrial genome for delineating Onchocerca volvulus transmission zones

KE Crawford, SM Hedtke, SR Doyle, AC Kuesel… - International Journal for …, 2024 - Elsevier
National programs in Africa have expanded their objectives from control of onchocerciasis
(river blindness) as a public health problem to elimination of parasite transmission …

Genomic epidemiology in filarial nematodes: transforming the basis for elimination program decisions

SM Hedtke, AC Kuesel, KE Crawford, PM Graves… - Frontiers in …, 2020 - frontiersin.org
Onchocerciasis and lymphatic filariasis are targeted for elimination, primarily using mass
drug administration at the country and community levels. Elimination of transmission is the …