Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Metastasis is the leading cause of death for cancer patients. During cancer progression, the
initial detachment of cells from the primary tumor and the later colonization of a secondary …

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live
births; the incidence of CHD is up to tenfold higher in human fetuses,. A genetic contribution …

A diffusion barrier at the transition zone enables the compartmentalization of signaling
molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which …

Membrane association with mother centriole (M-centriole) distal appendages is critical for
ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

The embryonic mouse fibroblast cell line NIH3T3 is widely used in life science research,
including the study of cell cycle control and primary cilia. Fibroblasts are the most important …

Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour
progression and therapeutic response depend on interactions between the cancer cells and …