A brief history of nearly EV‐erything–The rise and rise of extracellular vesicles
Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the
extracellular space. The field of EVs has grown exponentially over the past two decades; this …
extracellular space. The field of EVs has grown exponentially over the past two decades; this …
Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury
ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …
their families, but currently no drugs on the market promote neurological recovery. Limited …
Action plan for stroke in Europe 2018–2030
B Norrving, J Barrick, A Davalos… - European stroke …, 2018 - journals.sagepub.com
Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg
meetings, were convened to review the scientific evidence and the state of current services …
meetings, were convened to review the scientific evidence and the state of current services …
Astrocyte activation in neurovascular damage and repair following ischaemic stroke
A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow)
Background and Objectives The relevance of impaired microvascular tissue-level
reperfusion despite complete upstream macrovascular angiographic reperfusion (no-reflow) …
reperfusion despite complete upstream macrovascular angiographic reperfusion (no-reflow) …
Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice
H Zhang, J Wu, J Wu, Q Fan, J Zhou, J Wu… - Journal of …, 2019 - Springer
Background Accumulating evidence shows that microRNA-210 (miR-210) holds great
promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However …
promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However …
Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …
Potential circadian effects on translational failure for neuroprotection
Neuroprotectant strategies that have worked in rodent models of stroke have failed to
provide protection in clinical trials. Here we show that the opposite circadian cycles in …
provide protection in clinical trials. Here we show that the opposite circadian cycles in …
Pterostilbene attenuates astrocytic inflammation and neuronal oxidative injury after ischemia-reperfusion by inhibiting NF-κB phosphorylation
H Liu, X Wu, J Luo, X Wang, H Guo, D Feng… - Frontiers in …, 2019 - frontiersin.org
Astrocyte-mediated inflammation and oxidative stress elicit cerebral ischemia-reperfusion
(IR) injury after stroke. Nuclear factor (NF)-κB activates astrocytes and generates pro …
(IR) injury after stroke. Nuclear factor (NF)-κB activates astrocytes and generates pro …
Targeting the blood-brain barrier for the delivery of stroke therapies
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …