Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Vitamin D and uterine fibroids—review of the literature and novel concepts

M Ciebiera, M Włodarczyk, M Ciebiera… - International Journal of …, 2018 - mdpi.com
This article provides a detailed review of current knowledge on the role of vitamin D and its
receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for …

Dietary natural compounds and vitamins as potential cofactors in uterine fibroids growth and development

I Szydłowska, J Nawrocka-Rutkowska, A Brodowska… - Nutrients, 2022 - mdpi.com
An analysis of the literature generated within the past 20 year-span concerning risks of
uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin …

Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids

MS Islam, M Parish, JT Brennan, BL Winer… - Scientific reports, 2023 - nature.com
Fibrosis is characterized by excessive accumulation of extracellular matrix, which is a key
feature of uterine fibroids. Our prior research supports the tenet that inhibition of fibrotic …

Advanced 3D imaging of uterine leiomyoma's morphology by propagation-based phase-contrast microtomography

A Giuliani, S Greco, S Pacilè, A Zannotti… - Scientific reports, 2019 - nature.com
Uterine leiomyoma is the most common benign smooth muscle tumor in women pelvis,
originating from the myometrium. It is caused by a disorder of fibrosis, with a large …

Omega‐3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells

MS Islam, C Castellucci, R Fiorini… - Journal of cellular …, 2018 - Wiley Online Library
Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of
premenopausal women and new medical treatments are needed. This study aimed to …

Markers of cellular proliferation, apoptosis, estrogen/progesterone receptor expression and fibrosis in selective progesterone receptor modulator (ulipristal acetate) …

I Szydłowska, M Grabowska… - Journal of Clinical …, 2021 - mdpi.com
There appear to be very few data on the exact mechanisms of a selective progesterone
receptor modulator action in myomas. The aim of the study was to assess the effects of …

The in vitro effects of Romina strawberry extract on 3D uterine leiomyosarcoma cells

S Greco, P Pellegrino, F Giampieri, F Capocasa… - Nutrients, 2023 - mdpi.com
Leiomyosarcoma is an aggressive soft tissue sarcoma derived from the smooth muscle cells
of the uterus. We tested the effect of Romina strawberry extract treatment on three …

Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells

F Giampieri, MS Islam, S Greco… - Journal of Cellular …, 2019 - Wiley Online Library
Uterine leiom yomas are benign tumors highly prevalent in reproductive women. In
thecurrent study, initially, we aimed to screen five different strawberry cultivars (Alba, Clery …

Telocytes in the architecture of uterine fibroids

V Aleksandrovych, A Pasternak, K Gil - Folia medica Cracoviensia, 2019 - ruj.uj.edu.pl
Knowledge of uterine fibroids has existed since the time of Hippocrates. However, there are
still wide gaps in the understanding of its pathogenesis. No single theory explains the …