The antiphospholipid syndrome

JS Levine, DW Branch, J Rauch - New England Journal of …, 2002 - Mass Medical Soc
The antiphospholipid syndrome is an autoimmune disorder of hypercoagulability
characterized by the presence of autoantibodies to various phospholipids or phospholipid …

Serology of lupus erythematosus: correlation between immunopathological features and clinical aspects

E Cozzani, M Drosera, G Gasparini… - Autoimmune …, 2014 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
aberrant production of a broad and heterogenous group of autoantibodies. Even though the …

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Y Zuo, SK Estes, RA Ali, AA Gandhi… - Science translational …, 2020 - science.org
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung
histopathology often reveals fibrin-based blockages in the small blood vessels of patients …

Risk of developing antiphospholipid antibodies following viral infection: a systematic review and meta-analysis

N Abdel-Wahab, S Talathi, MA Lopez-Olivo… - Lupus, 2018 - journals.sagepub.com
Objective The objective of this paper is to conduct a systematic review and meta-analysis on
the risk of developing elevated antiphospholipid (aPL) antibodies and related …

Lipid–protein interactions in blood coagulation

RFA Zwaal, P Comfurius, EM Bevers - Biochimica et Biophysica Acta (BBA) …, 1998 - Elsevier
It has long been appreciated that lipids, particularly anionic phospholipids, promote blood
coagulation. The last two decades have seen an increasing insight into the kinetic and …

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

E Matsuura, Y Igarashi, T Yasuda, DA Triplett… - The Journal of …, 1994 - rupress.org
Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the
antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is …

Antiphospholipid antibodies and infections

RA Asherson, R Cervera - Annals of the Rheumatic Diseases, 2003 - ard.bmj.com
Many infections have been found to be associated with antiphospholipid antibodies (aPL),
although a pathogenic role for these antibodies has not usually been obvious except in a …

High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies

RS Rai, K Clifford, H Cohen, L Regan - Human reproduction, 1995 - academic.oup.com
Antiphospholipid antibodies (APA), lupus anticoagulant (LA) and/or anticardiolipin
antibodies (ACA), are associated with thrombosis and recurrent miscarriage. We studied the …

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to …

SM Alam, M McAdams, D Boren, M Rak… - The Journal of …, 2007 - journals.aai.org
Two neutralizing human mAbs, 2F5 and 4E10, that react with the HIV-1 envelope gp41
membrane proximal region are also polyspecific autoantibodies that bind to anionic …

Anti-cardiolipin antibodies and risk of myocardial infarction in a prospective cohort of middle-aged men

O Vaarala, M Mänttäri, V Manninen, L Tenkanen… - Circulation, 1995 - Am Heart Assoc
Background Data concerning the relation between anti-phospholipid (aPL) antibodies and
myocardial infarction in subjects without evidence of overt autoimmune disease are …