Emerging concepts and technologies in vaccine development

M Brisse, SM Vrba, N Kirk, Y Liang, H Ly - Frontiers in immunology, 2020 - frontiersin.org
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …

An overview of the vaccine platforms to combat COVID-19 with a focus on the subunit vaccines

F Bayani, NS Hashkavaei, S Arjmand, S Rezaei… - Progress in Biophysics …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that
has caused the recent coronavirus disease (COVID-19) global pandemic. The current …

A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2

W Tai, X Zhang, A Drelich, J Shi, JC Hsu, L Luchsinger… - Cell research, 2020 - nature.com
Dear Editor, The pandemic of coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the need to develop …

Current status of Zika virus vaccines: successes and challenges

A Pattnaik, BR Sahoo, AK Pattnaik - Vaccines, 2020 - mdpi.com
The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Q Geng, W Tai, VK Baxter, J Shi, Y Wan, X Zhang… - PLoS …, 2021 - journals.plos.org
The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety
of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS …

A glycosylated RBD protein induces enhanced neutralizing antibodies against Omicron and other variants with improved protection against SARS-CoV-2 infection

J Shi, J Zheng, W Tai, AK Verma, X Zhang… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 has mutated frequently since its first emergence in 2019.
Numerous variants, including the currently emerging Omicron variant, have demonstrated …

[HTML][HTML] Development of vaccines for SARS-CoV-2

WH Ng, X Liu, S Mahalingam - F1000Research, 2020 - ncbi.nlm.nih.gov
COVID-19 emerged in late 2019 and has rapidly spread through many countries globally.
The causative SARS-CoV-2 virus was not known until recently, and there is little or no …

Effective vaccination strategy using SARS-CoV-2 spike cocktail against Omicron and other variants of concern

J Shi, G Wang, J Zheng, AK Verma, X Guan… - npj Vaccines, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant harbors more than 30 mutations in its spike (S)
protein. Circulating Omicron subvariants, particularly BA5 and other variants of concern …

Computational tools for modern vaccine development

Sunita, A Sajid, Y Singh, P Shukla - Human vaccines & …, 2020 - Taylor & Francis
Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not
only arrest the beginning of different diseases but also assign a gateway for its elimination …

Identification of novel natural products as effective and broad-spectrum anti-Zika virus inhibitors

Y Gao, W Tai, N Wang, X Li, S Jiang, AK Debnath, L Du… - Viruses, 2019 - mdpi.com
Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome,
which includes microcephaly and other neurological malformations. No therapeutic agents …