Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …

Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …

Organoids represent both a potentially powerful tool for the study cell-cell interactions within
tissue-like environments, and a platform for tissue regenerative approaches. The …

The main function of the lung is to support gas exchange, and defects in lung development
or diseases affecting the structure and function of the lung can have fatal consequences …

Human pluripotent stem cell (hPSC) derived tissues often remain developmentally immature
in vitro, and become more adult-like in their structure, cellular diversity and function following …

Drug failure due to toxicity indicators remains among the primary reasons for staggering
drug attrition rates during clinical studies and post-marketing surveillance. Broader …

Stem cell technologies, especially patient-specific, induced stem cell pluripotency and
directed differentiation, hold great promise for changing the landscape of medical therapies …

Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …