In most cases, protein aggregation stems from the establishment of non-native
intermolecular contacts. The formation of insoluble protein aggregates is associated with …

Protein aggregation and amyloid formation have historically been linked with various
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …

Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core
cross-β scaffold, where novel and advantageous biological function is generated by the …

Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of
the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well …

Proteins and their aggregation is significant field of research due to their association with
various conformational maladies including well-known neurodegenerative diseases like …

Biofilms are bacterial communities that result from a cell differentiation process leading to
the secretion of an extracellular matrix (ECM) by part of the population. In Bacillus subtilis …

Side-chain motions play an important role in understanding protein structure, dynamics,
protein–protein, and protein–ligand interactions. However, our understanding of protein side …

F-specific filamentous phages, elongated particles with circular single-stranded DNA
encased in a symmetric protein capsid, undergo an intermediate step, where thousands of …

Dynamic and disordered regions in native proteins are often critical for their function,
particularly in ligand binding and signaling. In certain proteins, however, such regions can …

This mini-review represents a brief, disorder-centric consideration of the interplay between
order and disorder in proteins. The goal here is to show that inside the cell, folding, non …