Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Background: Progerin, an aberrant protein that accumulates with age, causes the rare
genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS …

Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS),
are caused by single point mutations. HGPS is a rare disorder that causes premature aging …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by
progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die …

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively
more prevalent in our societies. A better understanding of how aging promotes CVD is …

Importance Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare disorder
associated with premature death due to cardiovascular events during the second decade of …

Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized
by premature aging and death mainly because of myocardial infarction, stroke, or heart …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates
many symptoms of physiological aging and precipitates death. Patients develop severe …