There are currently more than 600 diseases characterized as affecting the central nervous
system (CNS) which inflict neural damage. Unfortunately, few of these conditions have …

Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Human brain development involves an orchestrated, massive neural progenitor expansion
while a multi-cellular tissue architecture is established. Continuously expanding organoids …

Background Neural induction of human pluripotent stem cells often yields heterogeneous
cell populations that can hamper quantitative and comparative analyses. There is a need for …

Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette
transporters is one of several mechanisms of multidrug resistance thought to impair …

Nature has developed materials that are integrated and effective at controlling their
properties of adhesiveness and cohesiveness; the chemistry of these materials has been …

Glioblastoma multiforme (GBM) are highly proliferative tumors currently treated by surgical
removal, followed by radiotherapy and chemotherapy, which are counteracted by …

This paper describes a gradient-generating microfluidic platform for optimizing proliferation
and differentiation of neural stem cells (NSCs) in culture. Microfluidic technology has great …