Improving protein stability is an important goal for basic research as well as for clinical and
industrial applications but no commonly accepted and widely used strategy for efficient …

Phosphorylation by protein kinases is a central theme in biological systems. Aberrant protein
kinase activity has been implicated in a variety of human diseases, therefore, modulation of …

Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular
localization, and stability. Here we estimate the effect of phosphorylation on protein binding …

Interaction specificity is a required feature of biological networks and a necessary
characteristic of protein or small-molecule reagents and therapeutics. The ability to alter or …

Antibodies (Abs) are a crucial component of the immune system and are often used as
diagnostic and therapeutic agents. The need for high‐affinity and high‐specificity antibodies …

Protein–peptide interactions play essential functional roles in living organisms and their
structural characterization is a hot subject of current experimental and theoretical research …

Many important protein–protein interactions are mediated by the binding of a short peptide
stretch in one protein to a large globular segment in another. Recent efforts have provided …

Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal
recessive Parkinson's disease. Both gene products, the Ser/Thr kinase PINK1 and the E3 …

Mutations, which result in amino acid substitutions, influence the stability of proteins and
their binding to biomolecules. A molecular understanding of the effects of protein mutations …

Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling.
However, how these enzymes can be involved in such a broad spectrum of physiological …