New aspects of vitamin D metabolism and action—Addressing the skin as source and target

D Bikle, S Christakos - Nature Reviews Endocrinology, 2020 - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions

DD Bikle, J Schwartz - Frontiers in endocrinology, 2019 - frontiersin.org
This review focuses on the biologic importance of the vitamin D binding protein (DBP) with
emphasis on its regulation of total and free vitamin D metabolite levels in various clinical …

Vitamin D binding protein: a historic overview

R Bouillon, F Schuit, L Antonio… - Frontiers in …, 2020 - frontiersin.org
Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP. This
protein was originally first discovered by its worldwide polymorphism and called Group …

The role of vitamin D in inflammatory bowel disease: mechanism to management

J Fletcher, SC Cooper, S Ghosh, M Hewison - Nutrients, 2019 - mdpi.com
Vitamin D has been linked to human health benefits that extend far beyond its established
actions on calcium homeostasis and bone metabolism. One of the most well studied facets …

[HTML][HTML] Vitamin D: production, metabolism and mechanisms of action

DD Bikle - 2015 - europepmc.org
Vitamin D production in the skin under the influence of sunlight (UVB) is maximized at levels
of sunlight exposure that do not burn the skin. Further metabolism of vitamin D to its major …

Vitamin D metabolites: analytical challenges and clinical relevance

N Alonso, S Zelzer, G Eibinger, M Herrmann - Calcified tissue international, 2023 - Springer
Recent research activities have provided new insights in vitamin D metabolism in various
conditions. Furthermore, substantial progress has been made in the analysis of vitamin D …

A randomized pilot study using calcitriol in hospitalized COVID-19 patients

YM Elamir, H Amir, S Lim, YP Rana, CG Lopez… - Bone, 2022 - Elsevier
The systemic illness associated with SARS-CoV-2 infection results in hospitalization rate of
380.3 hospitalizations per 100,000 population, overwhelming health care systems. Vitamin …

Vitamin D and rheumatic diseases: a review of clinical evidence

N Charoenngam - International Journal of Molecular Sciences, 2021 - mdpi.com
Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also
considered an immunomodulatory agent that regulates innate and adaptive immune …

[HTML][HTML] Vitamin D metabolism and guidelines for vitamin D supplementation

I Ramasamy - The Clinical Biochemist Reviews, 2020 - ncbi.nlm.nih.gov
Vitamin D is essential for bone health and is known to be involved in immunomodulation
and cell proliferation. Vitamin D status remains a significant health issue worldwide …

The free hormone hypothesis: when, why, and how to measure the free hormone levels to assess vitamin D, thyroid, sex hormone, and cortisol status

DD Bikle - Journal of Bone and Mineral Research Plus, 2021 - academic.oup.com
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of
hormones that otherwise circulate in blood bound to their carrier proteins is able to enter …