Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer
and aging. Here, we show that senescence occurs during mammalian embryonic …

Cell death is part of the lifecycle of every multicellular organism. Nineteenth-century
pathologists already recognised that organised forms of cell death must exist to explain the …

The predominant definition of apoptosis considers that the elimination of the apoptosing cell
is by heterolytic degradation following phagocytosis by an assisting scavenger …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …

Abstract A novel series of 1, 2, 3-triazole-thiazolidinone-carvone hybrid compounds has
been designed and synthesized using the copper-catalyzed Huisgen azide-alkyne 1, 3 …

The evolutionarily conserved catabolic process of autophagy involves the degradation of
cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain …

The concept that target tissues determine the survival of neurons has inspired much of the
thinking on neuronal development in vertebrates, not least because it is supported by …

Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases but
its relationship and role in disease progression remain unclear. Using genetic and …