Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Broken detailed balance and non-equilibrium dynamics in living systems: a review

FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …

Cell swelling, softening and invasion in a three-dimensional breast cancer model

YL Han, AF Pegoraro, H Li, K Li, Y Yuan, G Xu, Z Gu… - Nature physics, 2020 - nature.com
Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …

Cell–cell interfaces as specialized compartments directing cell function

B Belardi, S Son, JH Felce, ML Dustin… - … Reviews Molecular Cell …, 2020 - nature.com
Cell–cell interfaces are found throughout multicellular organisms, from transient interactions
between motile immune cells to long-lived cell–cell contacts in epithelia. Studies of immune …

Adhesion-based self-organization in tissue patterning

TYC Tsai, RM Garner… - Annual review of cell and …, 2022 - annualreviews.org
Since the proposal of the differential adhesion hypothesis, scientists have been fascinated
by how cell adhesion mediates cellular self-organization to form spatial patterns during …

The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes

M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …

Curvature fluctuations of fluid vesicles reveal hydrodynamic dissipation within the bilayer

HA Faizi, R Granek, PM Vlahovska - … of the National Academy of Sciences, 2024 - pnas.org
The biological function of membranes is closely related to their softness, which is often
studied through the membranes' thermally driven fluctuations. Typically, the analysis …

Mechanical forces in cell monolayers

T Chen, TB Saw, RM Mège… - Journal of Cell …, 2018 - journals.biologists.com
In various physiological processes, the cell collective is organized in a monolayer, such as
seen in a simple epithelium. The advances in the understanding of mechanical behavior of …

Engineering tissue-scale properties with synthetic cells: Forging one from many

AJ Lin, AZ Sihorwala, B Belardi - ACS Synthetic Biology, 2023 - ACS Publications
In metazoans, living cells achieve capabilities beyond individual cell functionality by
assembling into multicellular tissue structures. These higher-order structures represent …

Clustering on membranes: fluctuations and more

L Johannes, W Pezeshkian, JH Ipsen, JC Shillcock - Trends in cell biology, 2018 - cell.com
Clustering of extracellular ligands and proteins on the plasma membrane is required to
perform specific cellular functions, such as signaling and endocytosis. Attractive forces that …