Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …

Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …

The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies
of novel genes and cell signalling pathways regulating bone strength have focused on the …

Abstract Purpose of Review The periosteum, the outer layer of bone, is a major source of
skeletal stem/progenitor cells (SSPCs) for bone repair. Here, we discuss recent findings on …

Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it
associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt …

Skeletal stem cells (SSCs) generate the progenitors needed for growth, maintenance and
repair of the skeleton. Historically, SSCs have been defined as bone marrow-derived cells …

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes.
They have been proposed as therapeutic targets to diminish Wnt signaling output in …