Drivers and impacts of the most extreme marine heatwave events
Prolonged high-temperature extreme events in the ocean, marine heatwaves, can have
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …
severe and long-lasting impacts on marine ecosystems, fisheries and associated services …
Methods for enzyme library creation: Which one will you choose? A guide for novices and experts to introduce genetic diversity
Enzyme engineering allows to explore sequence diversity in search for new properties. The
scientific literature is populated with methods to create enzyme libraries for engineering …
scientific literature is populated with methods to create enzyme libraries for engineering …
Plant-type pentatricopeptide repeat proteins with a DYW domain drive C-to-U RNA editing in Escherichia coli
RNA editing converting cytidines into uridines is a hallmark of gene expression in land plant
chloroplasts and mitochondria. Pentatricopeptide repeat (PPR) proteins have a key role in …
chloroplasts and mitochondria. Pentatricopeptide repeat (PPR) proteins have a key role in …
[PDF][PDF] Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib
Reduced drug uptake is an important mechanism of chemoresistance. Down‐regulation of
SLC22A1 encoding the organic cation transporter‐1 (OCT1) may affect the response of …
SLC22A1 encoding the organic cation transporter‐1 (OCT1) may affect the response of …
Plant mitochondrial RNA editing factors can perform targeted C-to-U editing of nuclear transcripts in human cells
E Lesch, MT Schilling, S Brenner, Y Yang… - Nucleic Acids …, 2022 - academic.oup.com
RNA editing processes are strikingly different in animals and plants. Up to thousands of
specific cytidines are converted into uridines in plant chloroplasts and mitochondria whereas …
specific cytidines are converted into uridines in plant chloroplasts and mitochondria whereas …
Human DDX21 binds and unwinds RNA guanine quadruplexes
Guanine quadruplexes (G4s) are an important structure of nucleic acids (DNA and RNA)
with roles in several cellular processes. RNA G4s require specialized unwinding enzymes …
with roles in several cellular processes. RNA G4s require specialized unwinding enzymes …
Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition
The farnesoid X receptor (FXR) is a key sensor in bile acid homeostasis. Although four
human FXR isoforms have been identified, the physiological role of this diversity is poorly …
human FXR isoforms have been identified, the physiological role of this diversity is poorly …
SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
LC Young, N Hartig, I Boned del Río… - Proceedings of the …, 2018 - National Acad Sciences
Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on
BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS …
BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS …
MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis
J Kim, H Kwon, YK Shin, G Song… - Proceedings of the …, 2020 - National Acad Sciences
The Hippo pathway plays a pivotal role in tissue homeostasis and tumor suppression. YAP
and TAZ are downstream effectors of the Hippo pathway, and their activities are tightly …
and TAZ are downstream effectors of the Hippo pathway, and their activities are tightly …
Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1
In the past 30 years, Salmonella bloodstream infections have become a significant health
problem in sub-Saharan Africa and are responsible for the deaths of an estimated 390,000 …
problem in sub-Saharan Africa and are responsible for the deaths of an estimated 390,000 …