Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats

Y Fan, X Liang, R Wang, L Song - Brain research bulletin, 2017 - Elsevier
Morphine is a widely used analgesic for various types of pain. However, its efficacy is
impeded by development of hyperalgesia and tolerance. Melatonin has antinociceptive …