Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

Fish epidermal mucus contains innate immune components, secreted by globlet cells that
provide the primary defence against different pathogenic microbes and act as a barrier …

The immune system of fish is very similar to vertebrates, although there are some important
differences. Fish are free-living organisms from the embryonic stage of life in their aquatic …

An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

The innate immune system is the only defence weapon of invertebrates and a fundamental
defence mechanism of fish. The innate system also plays an instructive role in the acquired …

Complement C4, a key molecule in the complement system that is one of chief constituents
of innate immunity for immediate recognition and elimination of invading microbes, plays an …

The basal position of fish in vertebrate phylogeny makes them very attractive for genomic
and functional comparative immunity studies. Adaptive immunity arose early in vertebrate …

▪ Abstract C reactive protein, the first innate immunity receptor identified, and serum amyloid
P component are classic short pentraxins produced in the liver. Long pentraxins, including …

The innate immune system consists of a cellular and a humoral arm. Pentraxins (eg, the
short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the …