Negative regulation of cytokine signaling in immunity
A Yoshimura, M Ito, S Chikuma… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal
transducers and activators of transcription (JAK-STAT) pathway to promote gene …
transducers and activators of transcription (JAK-STAT) pathway to promote gene …
[HTML][HTML] SOCS proteins in development and disease
MC Trengove, AC Ward - American journal of clinical and …, 2013 - ncbi.nlm.nih.gov
Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …
proliferation, survival and function of a number of cell lineages. This is achieved via specific …
Quantitative interactomics in primary T cells provides a rationale for concomitant PD-1 and BTLA coinhibitor blockade in cancer immunotherapy
J Celis-Gutierrez, P Blattmann, Y Zhai, N Jarmuzynski… - Cell reports, 2019 - cell.com
Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental
and clinical interest. Using quantitative interactomics, we define the composition and …
and clinical interest. Using quantitative interactomics, we define the composition and …
The SOCS box—adapting proteins for ubiquitination and proteasomal degradation
EM Linossi, SE Nicholson - IUBMB life, 2012 - Wiley Online Library
The s uppressor ofc ytokine s ignalling (SOCS) box was first identified in the SH2‐containing
SOCS box family (cytokine‐inducible SH2‐containing protein, SOCS1–7) and is a 40‐amino …
SOCS box family (cytokine‐inducible SH2‐containing protein, SOCS1–7) and is a 40‐amino …
[HTML][HTML] Cullin-RING Ligase 5: Functional characterization and its role in human cancers
Abstract Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …
SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis
R Pandey, M Bakay, H Hakonarson - Frontiers in immunology, 2023 - frontiersin.org
Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …
and their development is intricately connected to the disruption of the JAK-STAT signaling …
Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins
EM Linossi, SE Nicholson - Immunological reviews, 2015 - Wiley Online Library
The suppressor of cytokine signaling (SOCS) family of proteins are key negative regulators
of cytokine and growth factor signaling. They act at the receptor complex to modulate the …
of cytokine and growth factor signaling. They act at the receptor complex to modulate the …
[HTML][HTML] Feedback regulation of RTK signaling in development
Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …
is critical for the execution of cellular programs and behaviors. Understanding these control …
RNA sequencing reveals distinct immune responses in the chorioamniotic membranes of women with preterm labor and microbial or sterile intra-amniotic …
Preterm labor precedes premature birth, the leading cause of neonatal morbidity and
mortality worldwide. Preterm labor can occur in the context of either microbe-associated intra …
mortality worldwide. Preterm labor can occur in the context of either microbe-associated intra …
[HTML][HTML] Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets
V Laletin, PL Bernard, CC da Silva… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting
mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs)(such as PD-1 and …
mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs)(such as PD-1 and …