Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes
Inflammation is a pathological feature of the pancreatic islet in type 1 and 2 diabetes,
contributing to islet endocrine cell failure and the onset of hyperglycaemia in both diseases …
contributing to islet endocrine cell failure and the onset of hyperglycaemia in both diseases …
[PDF][PDF] Suzanne E. Barbour1, 7, Phuong T. Nguyen1, 7, Margaret Park1, Bhargavi Emani1, Xiaoyong Lei2, Mamatha Kambalapalli1, Jacqueline C. Shultz1, Dayanjan …
M Kambalapalli, JC Shultz, D Wijesinghe, CE Chalfant - 2015 - academia.edu
Background: β-cell apoptosis, a critical contributor to T1D, involves iPLA2β activation and is
suppressed by Bcl-x (L). Results: iPLA2β-derived lipids activate an alternative 5'splice site …
suppressed by Bcl-x (L). Results: iPLA2β-derived lipids activate an alternative 5'splice site …