Capillary electrophoresis‐mass spectrometry for intact protein analysis: Pharmaceutical and biomedical applications (2018–March 2023)

K Maráková, M Opetová… - Journal of Separation …, 2023 - Wiley Online Library
Capillary electrophoresis is recognized as a valued separation technique for its high
separation efficiency, low sample consumption, good economic and ecological aspects …

Recent advances (2019–2021) of capillary electrophoresis‐mass spectrometry for multilevel proteomics

D Chen, EN McCool, Z Yang, X Shen… - Mass spectrometry …, 2023 - Wiley Online Library
Multilevel proteomics aims to delineate proteins at the peptide (bottom‐up proteomics),
proteoform (top‐down proteomics), and protein complex (native proteomics) levels. Capillary …

Fine-tuning the characteristic of the applied potential to improve AC-iEK separations of microparticles

NNN Ahamed, CA Mendiola-Escobedo… - Analytical …, 2023 - ACS Publications
There is an immediate need for the development of rapid and reliable methods for
microparticle and cell assessments, and electrokinetic (EK) phenomena can be exploited to …

Concepts and recent advances in microchip electrophoresis coupled to mass spectrometry: Technologies and applications

E Naghdi, GE Moran, ME Reinau… - …, 2023 - Wiley Online Library
The online coupling of microchip electrophoresis (ME) as a fast, highly efficient, and low‐
cost miniaturized separation technique to mass spectrometry (MS) as an information‐rich …

High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass …

Z Wu, H Wang, J Wu, Y Huang, X Zhao… - … of Pharmaceutical and …, 2023 - Elsevier
Therapeutic antibodies are a major class of pharmaceutical drugs used to treat a wide
variety of diseases. They have several advantages including the high specificity and binding …

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

L Pont, M Vergara‐Barberán… - …, 2024 - Wiley Online Library
This review provides an in‐depth exploration of capillary electrophoresis–mass
spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a …

Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics

E Makrydaki, P Kotidis, KM Polizzi… - Current Opinion in …, 2021 - Elsevier
N-glycosylation is of paramount importance for understanding the mechanisms of various
human diseases and ensuring the safety and efficacy of biotherapeutics. Traditional glycan …

[HTML][HTML] 治疗类糖蛋白的糖基化分析

汪泓, 尹红锐, 陈益乐, 方欣欣, 徐明明, 田橙, 徐进… - 药学学报, 2021 - html.rhhz.net
糖基化作为至关重要的一种蛋白质翻译后修饰, 在治疗类糖蛋白的安全性, 有效性,
质量可控性中起到关键性作用. 然而, 糖基化为非模板依赖性的酶促修饰, 具有天然的异质性 …

Impact of Microfluidic Chip Electrophoresis in Modern Analysis: An Update on Recent Trends

S Pasricha, R Bhatia, P Patel… - Current Analytical …, 2023 - benthamdirect.com
The recent development of microfluidics and lab-on-a-chip technology has substantially
raised interest in analytical chemistry. Since, they have demonstrated to be extraordinarily …

The Effect of Molecular Mass of Hydroxyethyl Cellulose on the Performance of Capillary Electrophoretic Separation of Proteins

J Huang, C Tao, Z Li, E Miyake, Q You, W Xiao… - Separations, 2022 - mdpi.com
Capillary electrophoresis (CE) is a versatile analytical separation method in the field of
biochemistry. Although it has been proved that the relative molecular mass (Mr) of the …