Physiology of the prion protein
Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
JM Moulis - Biometals, 2010 - Springer
The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …
human health despite attempts at limiting its technological uses. The biologically significant …
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model …
EM Toledo, NC Inestrosa - Molecular psychiatry, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
Copper as a key regulator of cell signalling pathways
Copper is an essential element in many biological processes. The critical functions
associated with copper have resulted from evolutionary harnessing of its potent redox …
associated with copper have resulted from evolutionary harnessing of its potent redox …
Ceruloplasmin and what it might do
J Healy, K Tipton - Journal of neural transmission, 2007 - Springer
The blue coloured plasma protein ceruloplasmin binds up to 95% of circulating copper, and
has several possible functions. It has been proposed to function in copper transport …
has several possible functions. It has been proposed to function in copper transport …
The relationship of copper to DNA damage and damage prevention in humans
MC Linder - … Research/Fundamental and Molecular Mechanisms of …, 2012 - Elsevier
Copper ions are well suited to facilitate formation of reactive oxygen species (ROS) that can
damage biomolecules, including DNA and chromatin. That this can occur in vitro with …
damage biomolecules, including DNA and chromatin. That this can occur in vitro with …
Metal ion physiopathology in neurodegenerative disorders
S Bolognin, L Messori, P Zatta - Neuromolecular medicine, 2009 - Springer
Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for
several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the …
several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the …
Structural consequences of copper binding to the prion protein
Prion, or PrPSc, is the pathological isoform of the cellular prion protein (PrPC) and it is the
etiological agent of transmissible spongiform encephalopathies (TSE) affecting humans and …
etiological agent of transmissible spongiform encephalopathies (TSE) affecting humans and …
Postsynaptic receptors for amyloid-β oligomers as mediators of neuronal damage in Alzheimer's disease
The neurotoxic effect of amyloid-β peptide (Aβ) over the central synapses has been
described and is reflected in the decrease of some postsynaptic excitatory proteins, the …
described and is reflected in the decrease of some postsynaptic excitatory proteins, the …
Interaction between prion protein's copper-bound octarepeat domain and a charged C-terminal pocket suggests a mechanism for N-terminal regulation
EGB Evans, MJ Pushie, KA Markham, HW Lee… - Structure, 2016 - cell.com
Copper plays a critical role in prion protein (PrP) physiology. Cu 2+ binds with high affinity to
the PrP N-terminal octarepeat (OR) domain, and intracellular copper promotes PrP …
the PrP N-terminal octarepeat (OR) domain, and intracellular copper promotes PrP …