Fluorescent tools have revolutionized our ability to probe biological dynamics, particularly at
the cellular level. Fluorescent sensors have been developed on several platforms, utilizing …

In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior,
leads to a comprehensive understanding of their conducts and the mechanisms in which …

The organization of the eukaryotic cell into discrete membrane-bound organelles allows for
the separation of incompatible biochemical processes, but the activities of these organelles …

Macrophages are key contributors to vascularization, but the mechanisms behind their
actions are not understood. Here, we show that diverse macrophage phenotypes have …

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we
now show that tumours reprogram a network of mitochondrial dynamics operative in …

The signaling events controlling proliferation, survival, and apoptosis during mammary
epithelial acinar morphogenesis remain poorly characterized. By imaging single-cell ERK …

Background Cancer is a highly complex disease, which involves the cooperation of tumor
cells with multiple types of host cells and the extracellular matrix. Cancer studies that rely …

Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their
accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and …

The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative
platform for drug discovery. This review provides an overview of the various model systems …

Background The goal of this survey paper is to overview cellular measurements using
optical microscopy imaging followed by automated image segmentation. The cellular …