RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …

Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain
unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as …

During the maternal-to-zygotic transition (MZT), maternal RNAs are actively degraded and
replaced by newly synthesized zygotic transcripts in a highly coordinated manner. However …

Protein-RNA networks are ubiquitous and central in biological control. We present an
approach termed RNA Tagging that enables the user to identify protein-RNA interactions in …

Uridylation emerges as a key modification promoting mRNA degradation in eukaryotes. In
addition, uridylation by URT1 prevents the accumulation of excessively deadenylated …

RNA–protein interactions permeate biology. Transcription, translation, and splicing all hinge
on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA …

Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications
promote RNA maturation, others may regulate function and stability. The 3′ terminal non …

Abstract Serine/arginine-rich (SR) proteins are conserved RNA-binding proteins that play
major roles in RNA metabolism. They function as molecular adaptors, facilitate spliceosome …

Groundbreaking discoveries have uncovered the widespread post-transcriptional
modifications of all classes of RNA. These studies have led to the emerging notion of an …