The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution
Venoms are one of the most convergent of animal traits known, and encompass a much
greater taxonomic and functional diversity than is commonly appreciated. This knowledge …
greater taxonomic and functional diversity than is commonly appreciated. This knowledge …
Piezo proteins: regulators of mechanosensation and other cellular processes
Piezo proteins have recently been identified as ion channels mediating mechanosensory
transduction in mammalian cells. Characterization of these channels has yielded important …
transduction in mammalian cells. Characterization of these channels has yielded important …
[HTML][HTML] Structural basis of Nav1. 7 inhibition by a gating-modifier spider toxin
Voltage-gated sodium (Nav) channels are targets of disease mutations, toxins, and
therapeutic drugs. Despite recent advances, the structural basis of voltage sensing …
therapeutic drugs. Despite recent advances, the structural basis of voltage sensing …
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
L Jammal Salameh, SH Bitzenhofer, IL Hanganu-Opatz… - Science, 2024 - science.org
The transmission of the heartbeat through the cerebral vascular system causes intracranial
pressure pulsations. We discovered that arterial pressure pulsations can directly modulate …
pressure pulsations. We discovered that arterial pressure pulsations can directly modulate …
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4
Cells can respond to mechanical stress by gating mechanosensitive ion channels (MSCs).
The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying …
The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying …
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads
Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …
potentials in excitable cells in both humans and insects. Many venomous animals have …
NaV1. 7 as a pain target–from gene to pharmacology
Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
Venom composition and strategies in spiders: is everything possible?
L Kuhn-Nentwig, R Stöcklin, W Nentwig - Advances in insect physiology, 2011 - Elsevier
This review on all spider venom components known by the end of 2010 bases on 1618
records for venom compounds from 174 spider species (= 0.41% of all known species) …
records for venom compounds from 174 spider species (= 0.41% of all known species) …
Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?
In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
Inhibition of Piezo1 attenuates demyelination in the central nervous system
M Velasco‐Estevez, KKE Gadalla, N Liñan‐Barba… - Glia, 2020 - Wiley Online Library
Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular
mechanical cues to intracellular molecular signaling cascades through a process termed …
mechanical cues to intracellular molecular signaling cascades through a process termed …