Predictive markers of immunogenicity and efficacy for human vaccines

M Van Tilbeurgh, K Lemdani, AS Beignon, C Chapon… - Vaccines, 2021 - mdpi.com
Vaccines represent one of the major advances of modern medicine. Despite the many
successes of vaccination, continuous efforts to design new vaccines are needed to fight “old” …

Noninvasive imaging in cancer immunotherapy: The way to precision medicine

Y Du, Y Qi, Z Jin, J Tian - Cancer letters, 2019 - Elsevier
Molecular medicine requires a more precise treatment directed at molecular aberrations
detected in tumors on an individual patient level. Immunotherapies empower the body's own …

Survivin-targeted immunotherapy drives robust polyfunctional T cell generation and differentiation in advanced ovarian cancer patients

NL Berinstein, M Karkada, AM Oza, K Odunsi… - …, 2015 - Taylor & Francis
DepoVax™ is an innovative and strongly immunogenic vaccine platform. Survivin is highly
expressed in many tumor types and has reported prognostic value. To generate tumor …

A respiratory syncytial virus vaccine based on the small hydrophobic protein ectodomain presented with a novel lipid-based formulation is highly immunogenic and …

JM Langley, LD MacDonald, GM Weir… - The Journal of …, 2018 - academic.oup.com
Background Respiratory syncytial virus infection can cause lower respiratory tract infection
in older adults comparable to influenza, but no vaccines are available. Methods This was a …

Using MRI cell tracking to monitor immune cell recruitment in response to a peptide‐based cancer vaccine

ML Tremblay, C Davis, CV Bowen… - Magnetic …, 2018 - Wiley Online Library
Purpose MRI cell tracking can be used to monitor immune cells involved in the
immunotherapy response, providing insight into the mechanism of action, temporal …

Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic …

GM Weir, O Hrytsenko, T Quinton, NL Berinstein… - … for immunotherapy of …, 2016 - Springer
Background Future cancer immunotherapies will combine multiple treatments to generate
functional immune responses to cancer antigens through synergistic, multi-modal …

Unique depot formed by an oil based vaccine facilitates active antigen uptake and provides effective tumour control

KD Brewer, GM Weir, I Dude, C Davis… - Journal of Biomedical …, 2018 - Springer
Background Oil emulsions are commonly used as vaccine delivery platforms to facilitate
slow release of antigen by forming a depot at the injection site. Antigen is trapped in the …

Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo

GM Weir, M Karkada, D Hoskin, MM Stanford… - PLoS …, 2017 - journals.plos.org
Vaccines that can rapidly induce strong and robust antibody-mediated immunity could
improve protection from certain infectious diseases for which current vaccine formulations …

Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal Bacillusanthracis spore inhalation challenge

GM Weir, LD MacDonald, R Rajagopalan, GS Sivko… - npj Vaccines, 2019 - nature.com
Anthrax is a serious biological threat caused by pulmonary exposure to aerosolized spores
of Bacillus anthracis. Biothrax®(anthrax vaccine adsorbed (AVA)) is the only Food and Drug …

Glycopolypeptide Coordinated Nanovaccine: Fabrication, Characterization, and Antitumor Immune Response

Y Song, L Teng, Y Chen, CM Dong - Chem & Bio Engineering, 2024 - ACS Publications
Cancer nanovaccine is a frontier immunotherapy strategy, in which the delivery carrier can
protect antigen and adjuvant from degradation, increase blood circulation half-life, and …