The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a
simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its …

Dextran has emerged as a promising biopolymer carrier for controlled release formulations
of pesticides. In this study, pH-sensitive acetalated dextran microparticles (Pyr@ Ac-Dex) are …

Current interstitial therapies for glioblastoma can overcome the blood–brain barrier but fail to
optimally release therapy at a rate that stalls cancer reoccurrence. To address this lapse …

Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic
ciprofloxacin (CIP) modalities into the intracellular compartments of macrophages owing to …

Nanoparticles (NPs) based on the biodegradable acetalated dextran polymer (Ac-Dex) were
used for near-infrared (NIR) imaging and controlled delivery of a PtIV prodrug into cancer …

Previously, high-aspect-ratio ribbon-like microconfetti (MC) composed of acetalated dextran
(Ace-DEX) have been shown to form a subcutaneous depot for sustained drug release. In …

Goniothalamin (GTN), a natural compound isolated from Goniothalamus species, has
previously demonstrated cytotoxic activity against several cancer cell lines. However …

Natural killer (NK) cells are an important member of the innate immune system and can
participate in direct tumor cell killing in response to immunotherapies. One class of …

Influenza infections are a health public problem worldwide every year with the potential to
become the next pandemic. Vaccination is the most effective strategy to prevent future …