DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

DNA-functionalized metal–organic framework nanoparticles for intracellular delivery of proteins

S Wang, Y Chen, S Wang, P Li, CA Mirkin… - Journal of the …, 2019 - ACS Publications
Due to their large size, charged surfaces, and environmental sensitivity, proteins do not
naturally cross cell-membranes in intact form and, therefore, are difficult to deliver for both …

Interface-driven hybrid materials based on DNA-functionalized gold nanoparticles

B Liu, J Liu - Matter, 2019 - cell.com
DNA-functionalized gold nanoparticles (AuNPs) are popular hybrid materials with
applications in directed assembly, biosensor development, and drug delivery. This system is …

Development of a DNAzyme walker for the detection of APE1 in living cancer cells

J Tao, H Zhang, M Weinfeld, XC Le - Analytical Chemistry, 2023 - ACS Publications
DNAzyme walker technology is a compelling option for bioanalytical and drug delivery
applications. While nucleic acid and protein targets have been used to activate DNAzyme …

CRISPR spherical nucleic acids

C Huang, Z Han, M Evangelopoulos… - Journal of the American …, 2022 - ACS Publications
The use of CRISPR/Cas9 systems in genome editing has been limited by the inability to
efficiently deliver the key editing components to and across tissues and cell membranes …

Gold nanoparticle size and shape effects on cellular uptake and intracellular distribution of siRNA nanoconstructs

J Yue, TJ Feliciano, W Li, A Lee… - Bioconjugate …, 2017 - ACS Publications
Gold nanoparticles (AuNPs) show potential for transfecting target cells with small interfering
RNA (siRNA), but the influence of key design parameters such as the size and shape of the …

Cellular processing and destinies of artificial DNA nanostructures

DS Lee, H Qian, CY Tay, DT Leong - Chemical Society Reviews, 2016 - pubs.rsc.org
Since many bionanotechnologies are targeted at cells, understanding how and where their
interactions occur and the subsequent results of these interactions is important. Changing …

Three-dimensional electron ptychography of organic–inorganic hybrid nanostructures

Z Ding, S Gao, W Fang, C Huang, L Zhou, X Pei… - Nature …, 2022 - nature.com
Three dimensional scaffolded DNA origami with inorganic nanoparticles has been used to
create tailored multidimensional nanostructures. However, the image contrast of DNA is …

DNA-mediated cellular delivery of functional enzymes

JD Brodin, AJ Sprangers, JR McMillan… - Journal of the American …, 2015 - ACS Publications
We report a strategy for creating a new class of protein transfection materials composed of a
functional protein core chemically modified with a dense shell of oligonucleotides. These …