Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis

K Dheda, T Gumbo, NR Gandhi, M Murray… - The lancet Respiratory …, 2014 - thelancet.com
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Green synthesis of silver nanoparticles by root extract of Premna integrifolia L. and evaluation of its cytotoxic and antibacterial activity

C Singh, SK Anand, R Upadhyay, N Pandey… - Materials Chemistry and …, 2023 - Elsevier
An efficient, reproducible, and eco-friendly protocol has been developed for the green
synthesis of silver nanoparticles using an aqueous root extract of Premna integrifolia (PE …

The association between sterilizing activity and drug distribution into tuberculosis lesions

B Prideaux, LE Via, MD Zimmerman, S Eum… - Nature medicine, 2015 - nature.com
Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming
emergence of drug resistance is the major objective of tuberculosis (TB) drug development …

[图书][B] South Africa pushed to the limit: The political economy of change

H Marais - 2011 - books.google.com
Since 1994, the democratic government in South Africa has worked hard at improving the
lives of the black majority, yet close to half the population lives in poverty, jobs are scarce …

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

MR Farhat, BJ Shapiro, KJ Kieser, R Sultana… - Nature …, 2013 - nature.com
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis
epidemic control. Mechanisms of resistance, including genetic changes favored by selection …

Serum drug concentrations predictive of pulmonary tuberculosis outcomes

JG Pasipanodya, H McIlleron, A Burger… - The Journal of …, 2013 - academic.oup.com
Background. Based on a hollow-fiber system model of tuberculosis, we hypothesize that
microbiologic failure and acquired drug resistance are primarily driven by low drug …

Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence …

AH Diacon, PR Donald, A Pym… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with
multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline …

Putting the patient back together—social medicine, network medicine, and the limits of reductionism

JA Greene, J Loscalzo - New England Journal of Medicine, 2017 - Mass Medical Soc
Putting the Patient Back Together â•fl Social Medicine, Network Medicine, and the Limits of
Reductionism Page 1 Medicine and Society The new england journal of medicine n engl j …

[HTML][HTML] Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa

M Klopper, RM Warren, C Hayes… - Emerging infectious …, 2013 - ncbi.nlm.nih.gov
Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape
Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible …